Found on every continent and every human-inhabited landmass on the planet, a vampire will often adopt the dress, mannerisms, and cultural subtleties representative of its host nation. Despite these superficial differences, the fundamental biology of the creature appears to remain consistent across cultures and societies. Detailed knowledge of the vampire’s anatomical structure is limited, as a full-scale vivisection of the creature has never been conducted; much about the vampire still remains a scientific mystery. However, enough information has been anecdotally confirmed to make ourselves a viable threat to the creature’s defenses. Since the intention of this work is to provide practical combative data rather than deep medical analysis, we will focus our anatomical discussion on details that have specific ramifications in a hostile engagement with a member of the vampire species.